If you’re pregnant and dealing with aches, headaches, or fever, you may wonder whether over-the-counter pain relievers are safe. On September 22nd, 2025, the American College of Obstetricians and Gynecologists (ACOG) issued a statement affirming the safety and benefits of acetaminophen (Tylenol) when used appropriately during pregnancy.
Why Acetaminophen Still Matters
ACOG emphasized that acetaminophen remains one of the few reliable options to treat fever, pain, or headaches for pregnant individuals. Left untreated, these symptoms themselves can pose risks to both the pregnant person and the baby. Their statement also pushed back against claims that acetaminophen causes neurodevelopmental disorders (like autism or ADHD), noting that to date, no strong, reputable study has confirmed such causal links.
In their words:
“In more than two decades of research … not a single reputable study has successfully concluded that use of acetaminophen in any trimester causes neurodevelopmental disorders in children.”
That said, ACOG also emphasizes the importance of using the lowest effective dose for the shortest duration possible, under guidance from your provider.
What This Means for You
- You shouldn’t avoid acetaminophen altogether just because you’re pregnant. It has an important, recognized role in managing pain and fever during pregnancy.
- Use as directed. Always follow label instructions or your provider’s guidance. Don’t exceed recommended daily limits.
- Talk with your OB or midwife. If you have questions or concerns, reach out to your OB or midwife.
- Watch for alternatives when possible. Nonpharmacologic measures—like rest, hydration, warm compresses, or gentle stretching—can help with mild discomforts. Acetaminophen is part of a toolbox, not always the first or only tool.
- Be cautious with other pain relievers. Some over-the-counter drugs (like NSAIDs) may not be safe during certain stages of pregnancy, making acetaminophen a safer option in many cases.
Safety Reminders During Pregnancy
If you’re expecting and experiencing discomfort, acetaminophen remains a trusted option—when used carefully. But it’s not a substitute for medical attention. Always:
- Discuss any medicines (even over-the-counter ones) with your provider
- Use the lowest dose that helps.
- Don’t self-medicate for prolonged periods.
- Monitor for side effects or changes you haven’t expected.
At Women First, we’re committed to helping expectant mothers make informed decisions for both their well-being and their baby’s. We’ll walk alongside you—supporting safe, evidence-based care every step of the way.
