Combination Hormonal Birth Control
Women First Care – Through every stage of life

Hormonal birth control options that contain a combination of estrogen and progestin include:
Most oral contraceptives, also referred to as “the pill,” contain a combination of female hormones, estrogen and progestin.
Several non-contraceptive benefits of the pill include a reduction in:
- Menstrual cramps or pain (dysmenorrhea)
- Acne
- Iron-deficiency anemia (a low blood count due to low iron levels)
- Ovarian cancer
- Uterine cancer
Other non-contraceptive benefits are treatment of:
- PMS (in many women)
- Perimenopausal problems
Side Effects
Possible side effects of the pill may include:
- Nausea, breast tenderness, bloating, and mood changes, which typically improve within two to three months without treatment.
- Breakthrough bleeding or spotting. This is particularly common during the first few months of taking oral contraceptives and almost always resolves itself without any treatment within two to three months. Missed or late pills can also cause breakthrough bleeding.
If you experience continuing side effects from taking birth control pills, talk with your Women First Care Team. The pill comes in many brands and formulations, and your Care Team can help you find the pill that’s best for you.
When taking the pill, you should notify your Women First Care Team for severe symptoms such as shortness of breath, chest pain, or severe leg pain.
Medication Interactions
The effectiveness of the pill may be reduced if you take certain medications.
Anticonvulsants: Some anticonvulsants, including phenytoin (Dilantin®), carbamazepine (Tegretol®), barbiturates, primidone (Mysoline®), topiramate (Topamax®) and oxcarbazepine (Trileptal®) can decrease the effectiveness of hormonal birth control methods (pill, patch, ring). These medications should be discussed with your doctor. Depo-medroxyprogesterone acetate [Depo-Provera®]) is NOT affected by any of these medications, and it actually reduces seizures in patients who have them, making it a good choice for women with seizures.
Other anticonvulsants DO NOT appear to reduce contraceptive efficacy, including gabapentin (Neurontin®), lamotrigine (Lamictal®), levetiracetam (Keppra®), and tiagabine (Gabitril®). However, there is some concern that oral contraceptives may reduce the effectiveness of lamotrigine, potentially increasing the risk of seizures.
Antibiotics: Rifampin, which is sometimes used to treat tuberculosis, can decrease the efficacy of hormonal birth control.
Other antibiotics (e.g., penicillin, cephalexin) DO NOT affect the efficacy of hormonal birth control methods.
St. John’s Wort: St. John’s wort, an herbal supplement sometimes taken to treat depression, may reduce the effectiveness of birth control pills.
Starting the Pill
When to expect a period: When the pill is taken on a 28-day cycle with 21 days of hormone pills followed by 7 days of placebo pills (“sugar pills”), your period usually occurs during the fourth week of the pill pack, i.e., the “placebo week.” However, some women have irregular breakthrough bleeding or spotting in the first few months. It is not necessary to take the placebo pills, but some women find it easier to remember to start their next pill pack if they have taken the placebos.
Shorter pill-free interval: Several pill formulations are available with 24 days of hormone pills (rather than 21) and only four days of placebo pills. This approach is designed to shorten and lighten periods, and minimize pill failures and side effects.
Continuous dosing: Some women prefer to take birth control pills continuously, which allows you to have fewer days of menstrual bleeding per year. This regimen is a particularly good treatment if you experience painful periods or endometriosis, as well as if you want to avoid a monthly bleed.
Some pills are designed and packaged for extended continuous dosing to have a period only every 3 months. Taking an oral contraceptive for an extended time results in fewer periods per year, although you may experience breakthrough bleeding when starting this regimen. Breakthrough bleeding is inconvenient, but does not indicate an increased risk of pill failure (unless you’ve forgotten to take any pills).
Traditional birth control pill packs can also be used in continuous dosing. In this regimen, you take the first three weeks of a pill pack (all the active pills), then immediately start a new pack (without a break); the last week of (placebo) pills is not used. This can be continued for as long as desired. This works best when all the active pills are the same pills (mono phasic not triphasic).
Birth control patches contain estrogen and progestin—similar to oral contraceptives—and are a week of pills in patch form. The patch is as effective as oral contraceptives and may be preferred since it does not require daily dosing. The failure rate of the patch may be higher for women who weigh more than 198 pounds.
Xulane® is the only patch contraceptive available in the United States. Effectiveness is similar to that of oral contraceptive pills.
The patch is worn for one week on the upper arm, shoulder, upper back, abdomen, or hip. After one week, the old patch is removed and a new patch is applied.
This is a great option for women who like birth control pills but don’t like daily responsibility. Risks and side effects are similar to those of oral contraceptives. Learn more about the patch here.
Nuvaring® is a soft flexible vaginal ring that contains estrogen and progestin, which is slowly absorbed through the vaginal tissues. The ring is changed monthly, and its position inside the vagina is not important.
Most women cannot feel the ring, and it is easy to insert and remove. If the ring is left out for more than 3 hours, a backup method of birth control (e.g., condom) should be used for the next 7 days.
This is a great option for women who like birth control pills but don’t like daily responsibility. Risks and side effects are similar to those of oral contraceptives. This is essentially a monthly pack of pills in vaginal ring form.
Sexual Health Is an Essential Aspect of Women’s Health
Family planning is an important part of life and allows you to plan ahead for the life and family you want.
Sexual Health is An Essential Aspect to Women’s Health
What People Are Saying
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Lauren Hayes25 September 2026Trustindex verifies that the original source of the review is Google.
Ultrasound tech, Emma, was phenomenal! She was so compassionate and took her time to make our experience great. We really appreciate the care she took during our ultrasound.Posted on Google![]()
Sidney12 August 2026Trustindex verifies that the original source of the review is Google.
Highly recommend! From the moment I walked in to the moment I walked out, my care was thoughtful, caring, and the furthest thing from feeling dismissed at a doctor’s office. Ellie did a wonderful job making me feel heard, comfortable and validate what I had been experiencing. For a first visit, I left feeling reassured and grateful that I chose this office.Posted on Google![]()
Charisa McMahon21 July 2026Trustindex verifies that the original source of the review is Google.
I highly recommend Audrey Fenwick. She truly takes the time to listen and never makes me feel rushed during my appointments. I always feel like my concerns are heard and taken seriously. What I appreciate most is that she’s willing to explore different treatment options rather than taking a one-size-fits-all approach. She works with me until we find a plan that we’re both comfortable with, and I always leave feeling confident that I’ve received thoughtful, personalized care. It’s refreshing to have a healthcare provider who is knowledgeable, compassionate, and genuinely invested in helping her patients feel their best.Posted on Google![]()
Amy Curry26 June 2026Trustindex verifies that the original source of the review is Google.
Dr. Shannon was a great provider during my last pregnancy with twins! She answered every question I had, kept me in the loop on all the clinical decisions and options I had available, and made me feel safe and heard during all of my interactions with her and her staff. All of the staff at Women’s first always took great care of me and my babies no matter what concern I had at the time.Posted on Google![]()
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They are always all so nice and welcoming. I just love Brook McAfee, APRN, she is awesome!Posted on Google![]()
Robin12 June 2026Trustindex verifies that the original source of the review is Google.
Dr Grider is the best Doctor. Very thorough, kind and personable!Posted on Google![]()
Cathy Carter4 June 2026Trustindex verifies that the original source of the review is Google.
I cannot tell you how pleased I am with the services provided by Dr. Anne L. Oliphant and the staff at Women First of Louisville. Dr. Oliphant and staff exhibit outstanding professionalism, punctuality and courtesy. I highly recommend Dr. Oliphant based on the fact that she is an exceptionally skilled and compassionate physician who truly takes the time to listen to her patients. Throughout my appointments, she and the staff made me feel completely at ease. She thoroughly explained my diagnosis and patiently answered all my questions without ever making me feel rushed. I had to do bloodwork during my last appointment. The clinicians and staff were especially friendly and professional as well. Dr. Oliphant’s, and the staff’s, empathetic bedside manner and clear communication elicit standout medical providers in the specialized field of menopause medicine. I believe that Dr. Oliphant has really listened to my concerns and has taken the time to support my health journey. I highly recommend her and the staff to anyone seeking personalized and highly effective care.Posted on Google![]()
Nancy Nance3 June 2026Trustindex verifies that the original source of the review is Google.
I have been a patient here for over 25 years. The best of care for any need I have had ! Simply the best !Posted on Google![]()
Kim Goff12 May 2026Trustindex verifies that the original source of the review is Google.
The care I've received at Women First of Louisville has been outstanding for over 15 years. It is amazing that such a large practice can be so efficient, organized, and caring all at the same time. For my annual checkups, I am able to schedule my mammogram and provider visit together. Pre-check in means I simply sign in and within a minute or two I'm called for my mammogram. Another 2-5 minute wait and I'm with a friendly, knowledgeable technician who completes the mammogram with a smile and a caring attitude. In 10 minutes, I am back in the waiting area and immediately called back for vitals by another friendly professional assistant. Within 5-10 minutes I am in the exam room and my provider, Heather McLennan, arrives. Here is where the appointment is less about efficiency and more about the care she provides to me. Heather always takes the time to speak with me...asking questions about my life, my health and my concerns. These are not just a check list. She listens. She smiles. She looks me in the eyes and participates in a conversation with me that makes me feel like she cares and understands. Her exam is gentle but thorough. I often have a question about recent research or options and she gives me her honest opinion based on facts. I completely trust her and the other women in all aspects of this practice. **A few years ago I did have a less than stellar experience with an assistant who took my vitals. She was dismissive and sloppy and made me feel uncomfortable when I didn't understand her questions. After I shared this experience with the check out staff, the office manager called me the same day for details, an apology and guarantee that the practice would address this as a training issue that would hopefully correct it. I've not seen or heard anything like it since. I am 100% satisfied with the care I receive at Women First of Louisville. I highly recommend you consider them for your healthcare needs.Posted on Google![]()
Carly Garcia11 May 2026Trustindex verifies that the original source of the review is Google.
Dr. Lauren Lewis is fabulous! She is extremely kind and patient, and she genuinely cares about those in her care. I felt very comfortable during my first appointment with her and have already recommended her to a friend!


